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DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division. The mechanism of action for quinolones, including moxifloxacin, is different from that of macrolides, aminoglycosides, or tetracyclines. Therefore, moxifloxacin may be active against pathogens that are resistant to these antibiotics and these antibiotics may be active against pathogens that are resistant to moxifloxacin.
There is no cross-resistance between moxifloxacin and the aforementioned classes of antibiotics. Cross-resistance has been observed between systemic moxifloxacin and some other quinolones.
In vitro resistance to moxifloxacin develops via multiple-step mutations. Resistance to moxifloxacin occurs in vitro at a general frequency of between 1. Moxifloxacin has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections as described in the Indications and Usage section:.
The following in vitro data are available, but their clinical significance in ophthalmic infections is unknown. The safety and effectiveness of MOXEZA in treating ophthalmic infections due to these organisms have not been established in adequate and well-controlled trials. Moxifloxacin has been shown to be active in vitro against most strains of the microorganisms listed below. These organisms are considered susceptible when evaluated using systemic breakpoints; however, a correlation between the in vitro systemic breakpoint and ophthalmologic efficacy has not been established.
The list of organisms is provided as guidance only in assessing the potential treatment of conjunctival infections. Aerobic Gram-positive microorganisms: Staphylococcus caprae Staphylococcus cohnii Staphylococcus lugdunensis Staphylococcus pasteuri Streptococcus agalactiae Streptococcus milleri group Streptococcus oralis Streptococcus pyogenes Streptococcus salivarius Streptococcus sanguis.
Aerobic Gram-negative microorganisms: Acinetobacter baumannii Acinetobacter calcoaceticus Acinetobacter junii Enterobacter aerogenes Enterobacter cloacae Haemophilus parainfluenzae Klebsiella oxytoca Moraxella catarrhalis Moraxella osloensis Morganella morganii Neisseria gonorrhoeae Neisseria meningitides Pantoea agglomerans Proteus vulgaris Pseudomonas stutzeri Serratia liquefaciens Serratia marcescens Stenotrophomonas maltophilia.
Anaerobic microorganisms: Clostridium perfringens Peptostreptococcus anaerobius Peptostreptococcus magnus Peptostreptococcus micros Peptostreptococcus prevotii. Other microorganisms: Mycobacterium tuberculosis Mycobacterium avium Mycobacterium kansasii Mycobacterium marinum. Long-term studies in animals to determine the carcinogenic potential of moxifloxacin have not been performed. Moxifloxacin was not mutagenic in four bacterial strains used in the Ames Salmonella reversion assay.
As with other quinolones, the positive response observed with moxifloxacin in strain TA using the same assay may be due to the inhibition of DNA gyrase. An equivocal result was obtained in the same assay when v79 cells were used.
Moxifloxacin was clastogenic in the v79 chromosome aberration assay, but it did not induce unscheduled DNA synthesis in cultured rat hepatocytes. There was no evidence of genotoxicity in vivo in a micronucleus test or a dominant lethal test in mice. In one randomized, double-masked, multicenter, vehicle-controlled clinical trial in which patients with bacterial conjunctivitis were dosed with MOXEZA 2 times a day, MOXEZA was superior to its vehicle for both clinical and microbiological outcomes.
Microbiologic eradication does not always correlate with clinical outcome in anti-infective trials. Tamper evidence is provided with a shrink band around the closure and neck area of the package. Advise patients not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis. Systemically administered quinolones, including moxifloxacin, have been associated with hypersensitivity reactions, even following a single dose.
Advise patients to discontinue use immediately and contact their physician at the first sign of a rash or allergic reaction [see Warnings and Precautions 5. DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed. DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use.
Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage , we no longer display the RxImage pill images associated with drug labels. We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels. View Package Photos. Drug Label Info. NDC National Drug Code - Each drug product is assigned this unique number which can be found on the drug's outer packaging.
Approval: Aerobic Gram-positive microorganisms: Staphylococcus caprae Staphylococcus cohnii Staphylococcus lugdunensis Staphylococcus pasteuri Streptococcus agalactiae Streptococcus milleri group Streptococcus oralis Streptococcus pyogenes Streptococcus salivarius Streptococcus sanguis Aerobic Gram-negative microorganisms: Acinetobacter baumannii Acinetobacter calcoaceticus Acinetobacter junii Enterobacter aerogenes Enterobacter cloacae Haemophilus parainfluenzae Klebsiella oxytoca Moraxella catarrhalis Moraxella osloensis Morganella morganii Neisseria gonorrhoeae Neisseria meningitides Pantoea agglomerans Proteus vulgaris Pseudomonas stutzeri Serratia liquefaciens Serratia marcescens Stenotrophomonas maltophilia Anaerobic microorganisms: Clostridium perfringens Peptostreptococcus anaerobius Peptostreptococcus magnus Peptostreptococcus micros Peptostreptococcus prevotii Other microorganisms: Mycobacterium tuberculosis Mycobacterium avium Mycobacterium kansasii Mycobacterium marinum.
Mutagenesis Moxifloxacin was not mutagenic in four bacterial strains used in the Ames Salmonella reversion assay. Brawley, CA Email: drugsdepot yahoo. Web: www. View Cart. Privacy Policy. Ryan Haight Act Disclosure. Notice to Consumers. Shipping, Return and Refused Policy. About Us. Contact Us. Call for Price. Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional.
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Orthodontist that take caresource in middke ga | Drug Label Info. The following in vitro data are available, but their clinical significance in ophthalmic infections is unknown. Aerobic Gram-positive microorganisms: Staphylococcus caprae Staphylococcus cohnii Staphylococcus lugdunensis Staphylococcus pasteuri Streptococcus agalactiae Streptococcus milleri group Streptococcus oralis Streptococcus pyogenes Streptococcus salivarius Streptococcus sanguis. The mechanism of action for quinolones, including moxifloxacin, is different from that of macrolides, alcon moxeza, or tetracyclines. Email: drugsdepot yahoo. We anticipate reposting the alcon moxeza once we are able identify and filter out images that do not match the information provided in the drug labels. |
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AzaSite Akorn, Inc. Ciloxan Alcon, a Novartis Division. Vigamox Alcon, a Novartis Division. Tobrex Alcon, a Novartis Division. Ocuflox Allergan. Zymaxid Allergan.
FDA Yes. CE Mark Not specified. Active Ingredients Moxifloxacin hydrochloride. Application Topical. Status Prescription. Strength 0. From Your Peers. Company Information Contact the company for additional information, availability, or pricing: Alcon, a Novartis Division alcon. Compare Antibiotic � 10 products �. MOXEZA will cause damage to the corneal endothelium if introduced directly into the anterior chamber of the eye. TASS is typically characterized by anterior chamber inflammatory reactions, such as fibrin, cell or flare and corneal edema, but other events, such as hypopyon, keratic precipitates or vitreous opacities may also occur.
In patients receiving systemically administered quinolones, including moxifloxacin, serious and occasionally fatal hypersensitivity anaphylactic reactions have been reported, some following the first dose.
Some reactions were accompanied by cardiovascular collapse, loss of consciousness, angioedema including laryngeal, pharyngeal or facial edema , airway obstruction, dyspnea, urticaria, and itching. If an allergic reaction to moxifloxacin occurs, discontinue use of the drug.
Serious acute hypersensitivity reactions may require immediate emergency treatment. Oxygen and airway management should be administered as clinically indicated. As with other anti-infectives, prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slit-lamp biomicroscopy, and, where appropriate, fluorescein staining.
Patients should be advised not to wear contact lenses if they have signs or symptoms of bacterial conjunctivitis. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to the rates in the clinical trials of another drug and may not reflect the rates observed in practice. The data described below reflect exposure to MOXEZA in patients, between 4 months and 92 years of age, with signs and symptoms of bacterial conjunctivitis.
Oral administration of moxifloxacin to pregnant rats and monkeys and intravenously to pregnant rabbits during the period of organogenesis did not produce adverse maternal or fetal effects at clinically relevant doses.
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Apr 28, �� Moxeza is a prescription medicine used to treat the symptoms of Bacterial Conjunctivits. Moxeza may be used alone or with other medications. Moxeza belongs to a . Moxeza� Manufacturer: Alcon: Country of Origin: Unknown: Alternate Manufacturer Number: Application: Antibiotic: Container Type: Dropper Bottle: Dosage Form: Solution: . 11 DESCRIPTION MOXEZA is a sterile solution for topical ophthalmic use. Moxifloxacin hydrochloride is an 8-methoxy fluoroquinolone anti-infective, with a diazabicyclononyl ring at .